Dr. Laura Creemers
UMC Utrecht, the Netherlands
Dr Creemers studied Biology and Biomedical Sciences. After her PhD on collage dagradation in soft connective tissue, she has worked in several research areas, including spermatogenic stem cells, ligament, tendon, bone and cartilage, before in 2005 finally focussing on cartilage and intervertebral disc (IVD) degeneration. With a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation, she has in the past years been involved in several projects on local drug delivery, including BMM IDiDAS (PI) targeting disc degeneration and BMM-OAcontrol on osteoarthritis.
In her ongoing projects, biomaterial-based delivery for inhibition of degeneration and stimulation of regeneration of the IVD and articular cartilage includes not only small molecules, proteins, peptides but also nucleic acids. Carriers vary from hydrogels and microparticles to nanoparticles. Delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration currently is most close to clinical translation. Research is done both in vitro and in in vivo models, ranging from rat to large animals, the latter in close collaboration with the dept of Companion Animals at the Faculty of Veterinary Medicine.